Information Theory: How do drugs interact with proteins?
Bipolar Disorder: How does lithium serve as an effective therapeutic?
Heart Disease: How does a mitochondrial transcription factor mutant lead to cardiomyopathies?
Mitochondrial Transcription: Several disease states have altered mitochondrial transcription.
Developing Autoimmune Disease Treatments: Autoimmune diseases such as lupus recognize “self” DNA as foreign pathogens. Can we exploit existing DNA binding proteins in the body as therapeutic agents?
Testicular Cancer: Can we target the HMGB4/DNA interaction in chemotherapy?
Understanding the Sox2/Promoter DNA mechanism: Several development diseases and cancer are associated with malfunctioning Sox2 function. Developing a greater understanding of this interaction at the molecular level could lead to novel therapeutics.