Enrique Cadenas' research programs address the molecular mechanisms inherent in brain aging and Alzheimer's disease under an umbrella that characterizes and evaluates quantitatively the decline in energy metabolism associated with brain aging and age-related neurodegenerative diseases by addressing the coordinated regulation of signaling and transcriptional pathways and mitochondrial function. This coordinated triad is critical in the regulation of brain glucose uptake and metabolism. This platform has been used to assess the therapeutic potential of several nutritional approaches that restore mitochondrial function and the associated signaling and transcriptional pathways as well as cognition (evaluated as long-term potentiation).